Osteocytes and Skeletal Pathophysiology
نویسندگان
چکیده
منابع مشابه
Pathophysiology of Skeletal Muscle
These lecture notes accompany my lectures on pathophysiology in the study module "Musculoskeletal System" at Innsbruck Medical University. The English version serves two purposes: as a learning aid for international students and to encourage German-speaking students to familiarize themselves with medical English; the lectures are delivered in German. The translation from the original German ver...
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The inaccessibility of osteocytes due to their embedment in the calcified bone matrix in vivo has precluded direct demonstration that osteocytes use gap junctions as a means of intercellular communication. In this article, we report successfully isolating primary cultures of osteocytes from chick calvaria, and, using anti-connexin 43 immunocytochemistry, demonstrate gap junction distribution to...
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Myostatin is an endogenous, negative regulator of muscle growth determining both muscle fiber number and size. The myostatin pathway is conserved across diverse species ranging from zebrafish to humans. Experimental models of muscle growth and regeneration have implicated myostatin as an important mediator of catabolic pathways in muscle cells. Inhibition of this pathway has emerged as a promis...
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PURPOSE OF REVIEW The bone is able to adapt its structure to mechanical signals via the bone remodeling process governed by mechanosensitive osteocytes. With aging, an imbalance in bone remodeling results in osteoporosis. In this review, we hypothesized that changes in lacunar morphology underlie the decreased bone mechanoresponsiveness to mechanical loading with aging. RECENT FINDINGS Severa...
متن کاملOsteocytes as multifunctional cells.
Bone is often thought of as being a passive, inactive tissue like a skeleton hanging in the anatomy lab. Often, bone tissue is envisioned statically in terms of two dimensions similar to a 'shapshot' of a histology slide. However, quite to the contrary, bone undergoes considerable turnover as compared to other organs in the body. Modeling during growth is dramatic and even in adult bone, 2-5% t...
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ژورنال
عنوان ژورنال: Current Molecular Biology Reports
سال: 2015
ISSN: 2198-6428
DOI: 10.1007/s40610-015-0026-y